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Beyond the metabolic rate reduction, hypothyroidism affects fat metabolism directly

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Although they can mediate control of many of the same intracellular pathways with many interconnected physiologic functions, the biological outputs influenced can also be exceptionally distinct as proven though the use of knockout models (Liu et al., 2000

FASEB J 30, 12843

So no, over-the-counter Alli is not as potent or effective as prescription-strength Xenical when it comes to blocking dietary fat absorption and assisting weight loss