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Simultaneous GHRH-R and GHSR-1a activation produces additive GH pulse amplification a model for studying maximal pituitary GH secretory capacity while maintaining physiologic pulse architecture

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With the increasing F1 peptide concentrations, from 0.8 to 3.2 M, the V max value decreased from 0.833 mol/mg/min to 0.645 mol/mg/min, K i value increased from 4.0 M to 5.82 M, and [I]/K i value increased from 0.2 to 0.55

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