How Tirzepatide Compares to Semaglutide The SURMOUNT-5 trial directly compared tirzepatide to semaglutide (Wegovy) over 72 weeks: Tirzepatide produced 47% greater weight loss than semaglutide in this head-to-head comparison
Alternatively, agents from different classessuch as SGLT-2 inhibitors or DPP-4 inhibitorscould be discussed if glycaemic targets allow
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B12 is water-soluble and excess is excreted renally, so toxicity is rare even with concurrent oral supplementation
Paget J (1854) Lectures on surgical pathology
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