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A new study in mice and humans suggests GLP-1 medicines drive weight loss primarily by reducing fat, while preserving muscle function and easing fears about harmful muscle wasting

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Fat Loss and Body Composition Elevated growth hormone supports fat metabolism, particularly around the abdomen, which is often the most stubborn area for men

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This physiological shift often results in pronounced metabolic dysregulation, including increased adiposity, insulin resistance, and impaired glucose tolerance [146]