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Common mechanisms of ferroptosis including iron overload, lipid peroxidation, GPX4 inhibition, and system Xc inhibition in obesity, which lead to decrease of GSH, increased ROS, and even ferroptosis
follow current UK SmPC for approved indications Patient monitoring should include regular assessment of: Body weight and composition to evaluate the effectiveness of weight management therapy Blood glucose levels , particularly in patients at risk of diabetes or with pre-existing diabetes Blood pressure , as both medications can affect cardiovascular parameters Gastrointestinal symptoms , ensuring tolerability of the combination Eye examinations for people with diabetes and pre-existing retinopathy, as rapid improvement in glucose control may temporarily worsen retinopathy Practical management strategies may help optimise outcomes: Timing Wegovy injections to minimise gastrointestinal side effects Implementing dietary modifications to support weight management despite steroid-induced appetite changes Ensuring adequate protein intake to counteract potential muscle loss from corticosteroids Maintaining physical activity as tolerated to support metabolic health Informing surgical teams about Wegovy use before procedures
S.SongR.et al (2021)
The clinically used GLP-1RAs are structurally modified GLP-1 analogs with dramatically increased half-lives relative to the native peptide (119)
Prader-Willi syndrome symptoms in early childhood With age, hypotonia tends to ease, while other PWS symptoms in infants may persist into early childhood
Hagen TM, Wierzbicka GT, Sillau AH, Bowman BB, Jones DP
