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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

doi:10.1007/S11095-009-9948-5

Preclinical Research Findings Exercise capacity In addition, Mouse studies reported greater running distance and duration together with an ERR-dependent acute aerobic-exercise transcriptional program